CBD Oil Side Effects Nobody Told You About

CBD Oil Side Effects

CBD oil — that magnificent, powerful phrase/product/cure that we have heard so much about. Everywhere you turn, there are praise and glory about its impact. However, rarely does one hear anything about CBD oil side effects, even though they are extremely important.

The “bad boy” THC is to be partially blamed for this. The public has been focused on its effects for so long, even trying to ban cannabis completely due to this psychoactive ingredient. Getting “high” used to be seen as the ultimate crime. At the same time, the medical benefits of cannabis were hard to deny. That said, when CBD was discovered, people were inclined to believe CBD effects are what makes cannabis such a powerful healer.

However, nothing is perfect, and neither is CBD. Contained in hemp oil or not, with or without some THC content, CBD oil comes with its fair share of downsides.

Let’s first take a quick look at what CBD is, and then you’ll find out everything there is to know about its detrimental effects.

CBD Basics

What Is CBD?

CBD (cannabidiol) is just one of many cannabinoids in the cannabis plant. CBD structure remains absolutely the same whether we’re talking about CBD from hemp (Cannabis Sativa) or the ‘’regular cannabis” (Cannabis Indica).

There are over 80 cannabinoids within cannabis. These natural substances have the ability to bind to our own endocannabinoid system. This is the reason why CBD is so efficient in the first place — our body recognizes it as a familiar substance. Luckily for us, CBD research suggests new incredible health benefits every day.

What Is CBD Oil?

To better understand CBD oil side effects, let’s first explain what the oil actually represents.

There are two types of CBD oil:

  • Pure CBD oil
  • Full-spectrum CBD oil.

The first one is guaranteed to have nothing else but CBD and carrier oil (olive, avocado, hemp seed oil, coconut oil, etc.). The latter comprises of CBD, THC, and all the other cannabinoids you can find in a cannabis plant. Terpenes come into the picture as well.

CBD oil can be taken in various ways — as the oil itself and as a CBD oil-infused product (CBD gummies, creams, lotions, patches, pills, and so on).

Side Effects of CBD Oil

Similar to any medicine, CBD oil comes with a (long) list of warnings. And just like it is the case with any other, the side effect may or may not exhibit themselves. Regardless of the reason, the fact remains that some people will endure the negative effects.

One of the biggest reasons for this is the fact that we are all different and that our bodies react individually to a stimulant. In addition to this, there are some things we can influence so as to avoid the side effects of CBD and get the maximum of its good sides.

Here are the most common disadvantages of CBD usage:


Whereas it is usually THC that is praised for a cannabis treatment for insomnia, CBD can make you drowsy as well. This is usually the case if you take a higher CBD dose than recommended. On the other hand, if you wish to avoid these CBD negative side effects, just take a smaller dose.


CBD is not cut out for a sensitive stomach or palate.

If you take CBD in the form of oil drops, you could feel sick. This is especially true if you take it on an empty stomach. The general rule of thumb applies here as well — take your medicine half an hour or an hour after a meal. Drink plenty of water afterward.

Due to its application, CBD cream side effects will include some other states, such as tiredness, but hardly ever nausea.

Appetite Boost or Loss

Depending on what you’re trying to achieve, this could be great for you. CBD oil products are very much praised for increasing appetite, particularly in cancer patients. In addition, CBD oil for anxiety and reduced anxiety levels usually encourage people to eat more. The appetite-boosting quality is mostly connected with full-spectrum CBD oil.

Dry Mouth

One of the most common CBD oil side effects is dry mouth. Basically, it is the feeling as if someone filled your mouth with cotton balls. It usually occurs if you’re using oil drops. The scientific experiment behind it suggests that CBD inhibits the endocannabinoid receptors in our brain, which are responsible for saliva production.

Luckily, dry mouth is only temporary and easily solved — just take a big glass of water after consuming CBD oil.


The side effects of CBD oil in dogs and humans may appear in this form. Here are two reasons why you may be experiencing this symptom:

  • As with any other medication, your body needs some time to adjust to it.
  • Since CBD oil alters your appetite, you may have changed your regular eating habits. Your gut gets revolted against the smaller or bigger food intake.

After one or two weeks, the symptoms should stop. Your body will adjust to CBD oil benefits and side effects and the new eating pattern. In case you are already suffering from diabetes or similar appetite/weight loss condition, be very careful about maintaining your goal weight.

Vivid Dreams

On the one hand, this oil will help you fall asleep faster. On the other hand, you may experience very realistic dreams during the first couple of nights. Even nightmares.

What happens is that CBD allows you to enter a deep sleep stage called N3, delta sleep, or slow-wave sleep. Luckily, you should be free of bad dreams after two days or as much as it takes your brain to adjust to the new substance.

CBD Oil Side Effects on Kidneys

There are some opposite opinions on this one. According to one study, cannabis is beneficial for patients with advanced chronic kidney disease (CKD). It helps them regulate the pain and exhibits no side issues.

In another research, though, it was found that cannabis has an adverse effect, especially if it’s consumed via smoking. Patients were advised against medical marijuana, and CBD oil possibly could have the same effect.

What are the side effects of CBD for healthy people? Apparently, none. Those who did not suffer from kidney disease did not show any reduction in kidney functions while using cannabis.


Dizziness due to CBD oil normally occurs if one takes a higher dose than they should. The easiest way for this to happen is during vaping. It takes some skill to master it because it isn’t the same as smoking a joint. Usually, people smoke concentrates rich in CBD, THC, and terpenes, so the “high” hits them unexpectedly.

To avoid side effects of vaping CBD, be moderate and careful about how you get the CBD vape oil.

Dizziness could be caused by low blood pressure too.

Parkinson’s Disease

CBD oil is actually recommended for treating Parkinson’s. Evidence of abuse is scarce.

Usually, patients are advised against using CBD if it interacts with some other medications. Mood changes, diarrhea, and tiredness may occur in these cases.

More serious side effects such as worsening the disease symptoms occur with too high dosage.

Grapefruit Warning

Grapefruit and CBD pills side effects can be identical. Grapefruit and similar fruit contain certain substances that interact with CYP450 enzymes in particular. In short, it prevents them from doing their job of dealing with the drugs we take. This way, too much medicine goes straight to the liver and isn’t processed before entering the bloodstream. Eventually, you end up with more drug that you are entitled to.

CBD behaves in a similar way. What is worse, it interferes with more enzymes (CYP3A4 and CYP2D6) and increases the drug level even more. Quitting CBD oil usage doesn’t let your body use the drug normally until a few days have passed.

In this respect, side effects of CBD oil will show if a person is taking some antidepressants, antihistamines, benzodiazepines, and statins.

To prevent the triggers in this case, be wary of the grapefruit warning on medications. Otherwise, CBD will turn the low dose of your medicine into a high dose.

CBD Oil Side Effects on Liver

This topic is pretty much intriguing, as it recently made the headlines.

Most articles that are against CBD oil usage rely on a mice study. Having been exposed to high CBD doses, they developed hepatotoxicity. However, what is usually omitted from catchy headlines is the fact that CBD was given in high doses. For example, the doses equaled what would be three and ten times bigger doses than the recommended one for Epidiolex.

Essentially, Epidiolex is pure CBD oil. It does come with a label warning about CBD hemp oil side effects, saying it should be used with caution if one is taking liver meds. Still, taking a dosage three times bigger is worrying no matter which medicine we are talking about.

Interestingly, CBD oil for liver cancer has shown some great effects, as there was even an example of a man coughing up dead cancer cells (!) after the CBD oil treatment.

To sum up, side effects are possible, but if your liver is healthy, they will occur only with extremely high doses.

Headaches and Migraines

When buying CBD oil of some kind, these CBD oil side effects may be listed on the label. In reality, the chances of CBD provoking headache are very low.

According to one study, CBD does not cause headaches or migraines. On the contrary, it is recommended as a cure.

The cause of headaches may have more to do with any substances or solvents added to the oil. Not all CBD oil for pain brands are reliable, so sometimes, a simple change of CBD brand will end the pain.

Reverse Tolerance

With CBD, you never know. Your body may develop tolerance to CBD effects after some time. This usually happens if your CBD oil contains THC. In contrast, you may be in for a surprise. CBD is also known to cause reverse tolerance. This means you will need a smaller dose after using CBD for a long time.

To be safe, monitor your doses and reactions.

Low Blood Pressure

The reason for lowering blood pressure could be that CBD may act as a blood thinner. If you’re already on blood-thinning meds, these side effects of CBD oil are very dangerous. For instance, even though CBD helps post-surgical pain and recovery, you shouldn’t be taking it one week before the operation.

CBD dilates blood vessels and is an excellent aid in preventing thrombosis or the formation of blood clots. But if you’re already using blood thinners, always consult your doctor.

Allergy to CBD

What are the side effects of CBD oil? Some of them are allergy symptoms.

An allergy to cannabis is a real thing. It manifests similarly to any other pollen allergy — runny nose, sneezing, rash, or itchy skin. The allergy may be provoked by airborne allergens, handling the plant (people working in the industry are especially at risk), or by eating some of the delicious edibles. What is more, you may have a mild allergy to cannabis, but it could make other allergies stronger, particularly food allergies.

If you are taking CBD oil for the first time, beware of these side effects of CBD oil in humans — dry cough, itchy eyes, sore throat, dry skin, blisters, hives, or watery eyes. Should you experience any of these, you may be having an allergic reaction to CBD oil.

CBD Oil Interactions With Other Drugs

Admittedly, the list is quite lengthy. We have already mentioned some precautions when we discussed blood thinners and liver meds. Here is what to pay special attention to if you’re using CBD.

It will interact with the following, so we strongly advise you against using CBD with:

  • Clobazam (Onfi), and
  • Valproate.

CBD may interact with:

  • Zonisamide
  • Topiramate (Topamax)
  • Sedative medications (CNS depressants), such as Nembutal, Luminal, Seconal, Duragesic, Sublimaze, morphine, Diprivan, Pentothal, and others.
  • Rufinamide (Banzel).

Side effects of CBD hemp oil can be shown if you use:

  • Medications that increase/decrease the breakdown of other medications by the liver:

Tagamet, Luvox, Prilosec, Ticlid, Topamax, Tegretol, Dilantin, Mycobutin, etc.

  • Medications that decrease the breakdown of other medications in the liver, such as:

Cordarone, Fortovase, Invirase, E-Mycin, Erythrocin, Cardizem, etc.

  • Medications changed by the liver:

Endometrin, Prometrium, Adalat CC, Procardia XL, Sandimmune, Xanax, Norvasc, Biaxin, Sandimmune, erythromycin, Mevacor, Nizoral, Sporanox, Allegra, Halcion, Calan, Isoptin and many others.

  • Eslicarbazepine (Aptiom).

Does CBD Oil Have Side Effects in Pregnancy?

As a matter of fact, nobody knows. The American College of Obstetricians and Gynecologists (ACOG) advises pregnant women against using cannabis in all its forms, CBD oil included.

So far, research on CBD oil dangers during pregnancy hasn’t been conducted. The existing studies all rely on cases when mothers-to-be were regular cannabis consumers. Smoking weed or eating cannabis during pregnancy is dangerous for the baby and may even cause stillbirth.

However, there is no evidence whatsoever that the use of CBD oil could cause the same consequences.

More Dangers of Using CBD Oil

This section has nothing to do with how your body processes CBD, but rather with side effects of CBD oil. It deals with whether or not you got what you paid for. Namely, CBD oil regulations are far from picture-perfect. Unless you are buying from a reliable source, you may experience some hardships.

Here are a couple of reasons which may repel you from consuming cannabidiol.

  • FDA — believe it or not, CBD oil is not FDA regulated. It is isn’t even listed as an FDA-approved dietary supplement. How is this possible? Most probably, the main reason for mistrust would be that cannabis is still listed as a Schedule 1 drug. Hence, it’s a bit challenging to do the paperwork for something similar to heroin (which belongs to Schedule 1 too).

CBD oil reviews without an official FDA stamp of approval may not be reliable at all. Not being FDA “blessed” gives enough chance to manufacturers to advertise the products as they wish and alter CBD oil’s content without harsh penalties.

  • Traces of THC — you could end up with more than you’ve bargained for. Some pure CBD oils may contain THC (even though they mustn’t). This is especially dangerous if a child is recommended pure CBD oil as THC is detrimental to young neural paths. In addition, that can make you positive on a drug test as THC lingers in your system for a long time. Not all drug tests can discover THC, though.
  • Harmful substances — sometimes, you may think you’re dealing with the negative side effects of CBD oil, but another substance is to blame. There are lots of CBD oil-infused products out there. Even if CBD oil is of perfect quality, it can be mixed with not-so-good ingredients.

The latest example comes in the form of vaping respiratory disease. It has already taken seven lives. The jury is still out, but the CBD vape oil side effects could be attributed to a harmful substance added to vaping liquid.

In addition, less reputable companies may treat the land and plants with poisonous pesticides to have a higher yield.

  • Insufficient amount of CBD — some CBD oils can have less CBD than it says on the label and more of carrier oil. Consequently, your condition requiring CBD won’t improve. Even worse, if you change the product but keep the dosage, you could overdose on CBD and experience all the negative side effects of CBD.
  • Type of use — interaction with other medications and similar side effects depend a lot on how exactly you are taking your recommended dose. CBD lotions or creams shouldn’t provide you with high doses of CBD. As for CBD edibles, CBD gummies side effects are felt less compared to taking CBD via vaping, smoking, or sublingually.


So what can we say about CBD oil in the end? First of all, don’t get carried away by the worldwide frenzy.

  • Always consult your doctor before taking any form of CBD oil.
  • Buy the oil only from reputable suppliers. These should always state their products were tested by independent laboratories, and their findings should be available. The same applies if you decide to make your own CBD oil. Always use the best ingredients.
  • To avoid CBD oil side effects, you are to stick to the recommended dose. The majority of issues are connected with overdosing.
  • Bear in mind how you take CBD oil — via CBD pills, oil, tincture, cream, edibles, or patches.

Finally, monitor your body and the results you get. CBD oil benefits are just too good to be missed. Hopefully, you are fully eligible to enjoy its advantages without any dangers to your health.

28 thoughts on “CBD Oil Side Effects Nobody Told You About

    1. Hi Janet,
      The general rule of thumb would be to take 10 to 15mg of CBD daily. Monitor how you feel and slowly increase the dosage if needed. Be extra careful about the CBD concentration in the oil you have purchased. If you suffer from any condition, you should consult with your physician before introducing any dosage to your treatment.

  1. so i smoke cbd all the time and when i fully charge my device and hit it multiple times my entire face goes numb starting with my eyes ears mouth then neck. it scares me everytime and i try drinking lots of water to counter the cbd. but most of the time it just has to run its toll. but it scares the absolute shit out of me, any tips?

    1. Hi Thomas! Thank you for contacting us. Here are some instructions by our dr. Djordjevic. First of all, you should check the dosage of CBD that you are using. Next, you should contact the CBD oil manufacturer. Also, check if they have third-party lab results. Reputable companies should have them publicly listed on their sites. Numbness is usually associated with THC, but I guess the product you are using is supposed to be THC-free? Companies also use different artificial additives so as to achieve the right taste and homogeneity. While some CBD vape oils have a couple of natural ingredients, others are loaded with artificial additives.

  2. Hi, how. Long does cbd oil remain in the body causing problems with other medications, regards Graham

    1. Hi Graham, thank you for your question. According to scientific studies, the half-life of CBD when taken orally is about 1 to 2 days. If you’re already taking some medications or plan on using them, make sure you consult with your doctor. Moreover, check which CBD oil would benefit you the most: isolate, full or broad spectrum. Have a good day!

  3. How can I be sure my cbd oil is as pure as advertised and that the source is reputable? What is the significance of time and heat on hemp and cbd oil? I am concerned that the product being offered to me is grown and warehoused in bales for a long time in one rural part of the USA, processed into product, shipped thousands of miles, and then warehoused again in a hot climate before further processing and eventual shipment to customers and then end-users. This scenario is real and raises food-safety concerns to me. Are my concerns valid? What protects consumers? These products are flooding into a demanding consumer market. Again, what concerns are valid? What are the effects of time and heat on hemp cbd oil products, esp. the tincture products that are taken directly sublingually?

    1. Hello Monica! Thank you very much for the comment. It’s true, the market is brimming with hemp and CBD products and since they are still not FDA regulated, there are some manufacturers that do not respect the guidelines. For this reason, we would recommend ordering CBD or cannabis products from one of the companies we have recommended (just take a look at our product or brand reviews). Some companies even offer a 60-day return policy, and all of them agree on returning the product if it arrived in poor shape.

      Usually, the storage practices are top-notch, but a company can’t always vouch for the shipment as the postal services are in charge of that (e.g. CBD gummies can melt a bit due to high temperatures). Hence the return policies. Tracking your order could help minimize the delivery time.

      I believe it would be best for you to choose a company and contact their client support for any specific information on shipping and storage. We are positive you will be completely satisfied with their explanation.

  4. Hello, is CBD oil the same as Hemp Extract? I just took my first CBD gummie containing 10mg Hemp Extract. I took it at 7:30 pm, and slept straight thru til 12:30 pm the next day (17 straight hours). After I awoke up, my entire face feels tingly and I’m so groggy. Is this normal? I bought my gummies from a reputable manufacturer that others I know also buy from.

    1. Hello Traci! From what you are saying, it seems that these gummies are very strong for you. Maybe you should try taking just half of the gummy? It’s not 100% precise technique, but it’s either that or buying gummies with less CBD per gummy. The reaction you felt is normal in the sense that this is what happens when you take a large dose. We are all individuals, so the dose that works wonders for your friend obviously is too potent for you.
      As for CBD oil equalling hemp extract, yes, this is usually the case (there are some false advertisers out there, so one has to be careful). However, bear in mind the hemp extract or CBD can be full-spectrum, broad-spectrum, or isolate, which also makes a difference.
      We hope that you find the right dosage. Let us know how it worked out for you!

  5. So Ive been taking about 10 drops of pure hemp oil with my tea to a help me sleep. On Tuesday night I took 50 drops by mistake, at 7.30 with my tea. WHAM – 10.30pm I wake up with the feeling that my head was exploding from the inside, then my neck – in an hour I was vomiting ….Now 40 hours later I’m still getting the head and neck pains but not as bad….

    Any thoughts on how long this will last and why this happened ?

    1. Hello Clive! What you have described sounds like overdosing on CBD. As with any medicine, the side effects and tolerance differ from person to person. Seems like you have experienced them strongly. I hope you are feeling better now!

  6. I gave my 9-year-old daughter 2 drops of 300mg CBD oil under her tongue 3 times. One in the evening and two times the next day one in the morning and one in the evening. For six months she has been having feeling like someone is punching her over and over again. Her symptoms are now 1000 times worse. She had gotten worse and worse each day. We have gone to the ER and talked with her doctor. They can only recommend ibuprofen and Epsom salt baths. Our anxiety level is at an all-time high. I am basically venting and sharing my experience with others. Thanks for letting me vent. Any thoughts?

    1. Hi Kim! Your daughter needs to be properly examined and diagnosed. Using CBD to treat symptoms is OK but you need to know the diagnosis and what you’re treating. Regards, Dr. Nikola

    1. Hello Lola! I’m pretty sure you are aware that taking CBD oil is helpful, but also there are a lot of other things one has to complete during the weight loss process. Best of luck to you!

  7. I put THC with CBD both 35mg cream Every morning on my shoulders for pain. It has worked good. Now I am having stomach nausea. Would this be from taking
    Every day for the past two weeks. Before that I was taking it periodically.
    Supply from a register store.

    1. Dear Janet,
      There is a possibility that this cream could cause nausea. In order to be absorbed, it would have to be applied to wide skin areas and in thick layers consistently. In the case of absorption, other side effects would probably follow, such as dizziness, mild confusion, and low muscle tone. In general, these side effects are very rare and highly unlikely to happen, if only used on shoulders, once a day.
      It’s more probable that oral medications or supplements would cause such an event if you are using any.
      If the cream is the only thing you’re using at the moment, you should restrain from using it for a week. If the pain disappears, you can start over but use it responsibly.
      If you’ve stopped the cream and nausea still persists, please, contact your attending medical professional doctor for further advice.
      Keep safe!

    1. Dear Sandra,

      Generally, there are no interactions when combining CBD-based creams and statins, so you can safely apply it.
      Be sure that you are applying the cream in accordance with the instructions on the label.
      Also, bear in mind that statins by themselves can on rare occasions give a skin rash. In that case, a skin reaction would be localized on several body areas, not only on the part where you apply the cream.

      Take care!

  8. Use the oil for arthritis, when waking up in am had problem with seeing bright colors of yellow –and bue. Only last a few minutes but enough to scare me . This has happened two times six mo. Between episodes. Thank you .Della

  9. I have been taking a CBD THC tincture for about a month continuously and I have recently developed a cough in the morning and sometimes a night. No pain, just a cough. Can it be from this tincture?

    1. Hello Leslie,
      What you have described sounds like a mild allergic reaction to CBD, provided that all the other conditions are ruled out. For example, whether the tincture has some other ingredients besides CBD extract and the carrier oil, or perhaps you have exposed yourself to some new substances in your environment recently. I would advise stopping the intake for a week and monitoring the changes (if any).

  10. Hi I took the pen and the next day I started getting all these side effects like dizziness, nausea, vivid dreams, loss of appetite, diarrhea, headaches that turn into migraines, I had a migraine for three days and I’m not sure what to do

    1. Hi Melissa, everyone reacts to CBD (or some component of CBD vaping oil) differently. I would advise you to stop using it and see whether your symptoms subside.

  11. i got some cbd drops from a local dispensary i love it for panic attacks and intrusive thoughts but i seem to be getting an itchy throat from it. this has never happened in the past with other oils. would it be the lemon flavoring added to it? it’s an essential oil

    1. Yes, that could be the case. Citrus-based ingredients can act as astringents – substances that contract proteins by absorbing water from the tissue.
      Always study the list of ingredients closely to check for potential irritants.
      There are lots of CBD companies out there adding artificial and natural compounds to improve oil taste or texture. While they are proclaimed safe, that doesn’t mean they’re suitable for everyone.
      I’d recommend taking a look at our page. You can find lots of CBD oil options that only have CBD oil and carrier oil as their ingredients.

Leave a Comment

Your email address will not be published. *